(2.11) Gender based difference in relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) in newly diagnosed type 2 diabetes (T2DM) men and women in Indian Kashmir.

Many studies have shown that the SUA level is independently associated with NAFLD in patients with T2DM and its elevation is an independent risk factor for NAFLD.

However, there is a scarcity of data on gender based difference in relationship between the two especially in T2DM. We aim to study the gender based difference in relationship between SUA and NAFLD in newly diagnosed T2DM Indian men and women.

 

Methods:

Study Design: Cross-sectional, Prospective observational study.

Sample size: 400 patients >18 years of age.

Data collection: 2 year period (from January 2018 to Jan2020.).

Participants: All consenting recently diagnosed (within last 6 months) T2DM patients attending the department of Endocrinology at SKIMS Srinagar.

Methods:

Methods:
1.Clinical data and biochemical profile including liver and kidney function parameters were collected.

2.Patients were stratified according to gender and presence/absence of NAFLD.

3.Parameters associated with NAFLD were identified using multivariate stepwise linear regression and univariate/multivariate logistic regression.

Results: 1.The prevalence of NAFLD by Ultrasound examination was 64% (n=87).

2.SUA was higher in the NAFLD group than in the non-NAFLD group for both men and women (P = 0.024).

3.Pearson correlation analysis revealed that SUA level was positively correlated with BMI (P=.003), triglycerides (P=.009), aspartate aminotransferase (P=.036), and alanine aminotransferase (P=.038) and negatively correlated with eGFR in both men and women.


4.Multivariate logistic regression revealed increased odds of NAFLD for SUA tertile 2 (P = 0.012) and 3 (P = 0.001) in women and tertile 3 (P = 0.04) in men.
5. After adjustment for multiple clinical parameters, SUA tertiles were significantly associated with NAFLD for tertile 3 in women (P = 0.012).

Discussion/Conclusion:

Our study demonstrates a positive association between SUA level and NAFLD prevalence that is stronger in women than in men. However, independent association between SUA and NAFLD couldn’t be established in either gender with T2DM.